Oxydolor 80mg (Oxycodone hydrochloride)

Duration of treatment.

The medicine should not be used longer than necessary. If long-term therapy is necessary due to the type and severity of the disease, careful and regular monitoring is recommended to determine whether and to what extent treatment should be continued. If opioid therapy is no longer indicated, a gradual reduction of the daily dose is recommended to prevent withdrawal symptoms.

Special patient groups

Elderly patients, unless they have evidence of hepatic and/or renal impairment, usually do not require dose adjustment. Particular caution should be exercised when initiating treatment in patients with renal or hepatic impairment. The recommended starting dose should be 50% of the adult dose (e.g. total daily dose of 10 mg in opioid-naïve patients). Dose adjustments should be made according to the individual clinical condition of the patient.

Method of administration

The tablets can be taken with or without meals and with sufficient fluid; they should be swallowed whole, not crushed, chewed, divided or crushed.

Side effects Oxydolor 80mg:

The most common side effects are nausea (especially at the beginning of treatment) and constipation. The main risk associated with opioid overdose is respiratory depression, which occurs most often in elderly or debilitated patients. In sensitive patients, opioids may cause a severe drop in blood pressure. 

Other side effects:

Very common: sedation (drowsiness up to impaired consciousness), dizziness, headache, constipation, nausea, vomiting, itching. Common: decreased appetite up to loss of appetite, mood and personality changes (e.g. anxiety, depression, euphoria), decreased activity, anxiety, psychomotor hyperactivity, agitation, nervousness, insomnia, abnormal thinking, confusion, fainting, paresthesia, hypotension, shortness of breath , abdominal pain, diarrhea, dry mouth, hiccups, indigestion, skin reactions/rash, urinary retention, painful urination, bladder urge, sweating, also with chills, weakness. 

Uncommon:

hypersensitivity, perception disorders (e.g. hallucinations, lack of consciousness), decreased sex drive, concentration disorders, migraine, taste disturbances, increased muscle tension, muscle tremors, uncontrolled muscle movements, hypoaesthesia, coordination disorders, vision disorders, hearing disorders, tachycardia, vasodilation, voice changes, cough, mouth ulceration, stomatitis, flatulence, biliary colic, impotence, physical dependence including withdrawal symptoms, pain (e.g. chest pain), malaise, edema , accidental injuries. Rare: herpes, dehydration, increased appetite, seizures (especially in people with epilepsy or prone to seizures), amnesia, palpitations, tarry stools, dental disease, bleeding gums, dysphagia, dry skin, amenorrhea, increase or decrease body weight, thirst. 

Very rare:

anaphylactic reactions, speech disorders, intestinal obstruction, increased liver enzymes, urticaria. Due to its pharmacological properties, oxycodone may cause respiratory depression, miosis, bronchospasm and smooth muscle spasm, and may abolish the cough reflex. Tolerance to the drug may occur. The risk of psychological dependence is significantly lower if the drug is used as directed.